Tattersall TL, et al. Nature Neuroscience 2014 Mar;17(3):449-54
Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus
The pedunculopontine nucleus (PPN) is a part of the mesencephalic locomotor region and is thought to be important for the initiation and maintenance of gait. Lesions of the PPN induce gait deficits, and the PPN has therefore emerged as a target for deep brain stimulation for the control of gait and postural disability. However, the role of the PPN in gait control is not understood. Using extracellular single-unit recordings in awake patients, we found that neurons in the PPN discharged as synchronous functional networks whose activity was phase locked to alpha oscillations. Neurons in the PPN responded to limb movement and imagined gait by dynamically changing network activity and decreasing alpha phase locking. Our results indicate that different synchronous networks are activated during initial motor planning and actual motion, and suggest that changes in gait initiation in Parkinson's disease may result from disrupted network activity in the PPN. This study provides new insight into how PPN DBS may potentially affect gait performance in PD patients.
Ziv Williams, Boston, MA
Odkerken VJ, et al. Lancet Neurology 2013 Jan;12(1):37-44.
Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial.
This group from the Netherlands assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic nucleus (STN) DBS. They randomly assigned patients to receive either GPi DBS or STN DBS. Patients and study assessors (but not those who assessed adverse events) were masked to treatment allocation. The two primary outcomes were functional health as measured by the weighted Academic Medical Center Linear Disability Scale and a composite score for cognitive, mood, and behavioural effects up to 1 year after surgery. Secondary outcomes were symptom scales, activities of daily living scales, a quality-of-life questionnaire, the occurrence of adverse events, and drug use. The study found that found no statistically significant difference in either of the primary outcomes when comparing GPi to STN treatment. There were similar cognitive, mood, and behavioural side-effects. Secondary outcomes showed larger improvements in off-drug phase, the mean change in ALDS scores and levodopa equivalent drug reduction in the STN group compared with the GPi group. Other secondary endpoints showed no difference between the groups. Although there was no difference in our primary outcomes, these findings suggest that STN could be considered the preferred target for DBS in patients with advanced PD.
Ziv Williams, Boston, MA
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2014 Philip L. Gildenberg, MD, PhD Stereotactic and Functional Resident Award.
Contratulations to Joshua Aronson, MD, who received the 2014 Philip L. Gildenberg, MD, PhD Stereotactic and Functional Resident Award for his paper entitled "Striatal Simulation for enhancement of Recovery in a Rodent Traumatic Brain Injury Model."
WSSFN Ohye and Tsubokawa Awards
The WSSFN leadership bestowed two awards in honour of deceased professors Ohye and Tsubokawa during the WSSFN congress in 2013 in Tokyo. The awards went to Dr. Clement Hamano (Ohye award) and Dr. Itzhak Fried (Tsubokawa award). For more information Click here to download
2011 Philip L. Gildenberg, MD, PhD Stereotactic and Functional Resident Award.
Contratulations to Patrick Schweder, MD, who received the 2011 Philip L. Gildenberg, MD, PhD Stereotactic and Functional Resident Award.
Contratulations to Demiter Serletis, MD, who received the 2010 Philip L. Gildenberg, MD, PhD Stereotactic and Functional Resident Award for his paper entitled "Multifractal Complexity in Epileptiform Hippocampal Dynamics" at the CNS meeting in Philadelphia. Below is a picture of Dr. Serletis receiving the award from Dr. Gildenberg.
Congratulations to the following recipients of the ASSFN Resident and Fellow Awards at the 2008 meeting in Vancouver, British Columbia.
Hong Yu, MD - "Predicting Brain Shift in Deep Brain Stimulation Surgery"
Hong Yu, Benjamin Rosenbaum, Pierre-Francois D'Haese, Srivatsan Pallavaram, Prashanth Dumpuri, Benoit M. Dawant, Joseph S. Neimat, Peter E. Konad. Vanderbilt University, Nashville, TN
Witold Libionka, MD - "A Central Role for Adenosine in Deep Brain Stimulation"
Witold Libionka. Jagiellonian University School of Medicine, Cracow, Poland.
Sepehr Sani, MD - "Chronic Stimulation Of The Posterior Hypothalamic Region For Cluster?Headache: Twenty One Month Follow Up Results In Eight Patients"
Sepehr Sani, Shoichi Shimamoto, Nicholas M. Barbaro, Abraham J. Nagy, Philip A. Starr. University of California San Francisco, San Francisco, CA.
AANS Sponsored Awards
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Progress in Neurological Surgery vol 29: “Stimulation of the Peripheral Nervous System: The Neuromodulation Frontier. Ed. K.V. Slavin. Karger
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